Tri-Marker Proliferation Index for Prostate Cancer Recurrence Prediction
Author Information
Author(s): Malhotra Sameer, Lapointe Jacques, Salari Keyan, Higgins John P., Ferrari Michelle, Montgomery Kelli, van de Rijn Matt, Brooks James D., Pollack Jonathan R.
Primary Institution: Stanford University
Hypothesis
Can a combination of tissue biomarkers predict biochemical recurrence after prostate cancer surgery?
Conclusion
The tri-marker proliferation index significantly improves prognostic performance for predicting biochemical recurrence in prostate cancer patients.
Supporting Evidence
- Each of the three proliferation markers was prognostic on its own.
- Combining the three markers into a proliferation index provided superior prognostic performance.
- The composite proliferation index remained a significant predictor in multivariate analysis.
Takeaway
Doctors can use a special test that looks at three markers in prostate cancer to better predict if a patient will have problems after surgery.
Methodology
The study analyzed immunohistochemical staining of three proliferation markers in a tissue microarray of prostate cancer cases.
Limitations
The study is limited to a specific cohort and requires validation in additional populations.
Participant Demographics
Patients were treated by radical prostatectomy with a median follow-up of eight years.
Statistical Information
P-Value
0.001
Confidence Interval
1.4–4.9
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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