Bile Acids and Insulin Sensitivity
Author Information
Author(s): Cariou Bertrand, Chetiveaux Maud, Zaïr Yassine, Pouteau Etienne, Disse Emmanuel, Guyomarc'h-Delasalle Béatrice, Laville Martine, Krempf Michel
Primary Institution: INSERM, UMR915; Université de Nantes; CHU Nantes, Clinique d'Endocrinologie, Maladies Métaboliques et Nutrition, l'Institut du Thorax, Nantes, CRNH Nantes, France
Hypothesis
Are fasting plasma bile acid concentrations linked to insulin sensitivity in humans?
Conclusion
Higher concentrations of plasma bile acids are associated with lower insulin sensitivity in various subjects.
Supporting Evidence
- Plasma CDCA and CA concentrations were negatively associated with insulin sensitivity.
- Total plasma bile acids were higher in obese and T2D subjects compared to healthy controls.
- Insulin sensitivity was assessed using the hyperinsulinemic-euglycemic clamp method.
Takeaway
This study found that certain bile acids in the blood can affect how well our bodies use insulin, which is important for controlling blood sugar.
Methodology
The study measured fasting plasma bile acids, glucose, insulin, and other metabolic parameters in healthy volunteers, obese subjects, and type 2 diabetes patients.
Limitations
Not all components of the plasma bile acid profile were analyzed, which may affect the results.
Participant Demographics
14 healthy volunteers, 20 patients with type 2 diabetes, and 22 non-diabetic abdominally obese subjects.
Statistical Information
P-Value
p = 0.001 for CDCA, p = 0.09 for CA, p < 0.0001 for DCA
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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