Porphyromonas gingivalis Gingipains Trigger a Proinflammatory Response in Human Monocyte-derived Macrophages Through the p38α Mitogen-activated Protein Kinase Signal Transduction Pathway
2010
Gingipains from Porphyromonas gingivalis Cause Inflammation in Macrophages
publication
Evidence: moderate
Author Information
Author(s): Daniel Grenier, Shin-ichi Tanabe
Primary Institution: Université Laval
Hypothesis
Can P. gingivalis gingipains trigger a proinflammatory response in human macrophages?
Conclusion
P. gingivalis gingipains induce a significant inflammatory response in macrophages, contributing to periodontitis.
Supporting Evidence
- Both Arg- and Lys-gingipains induced the secretion of TNF-α and IL-8 by macrophages.
- Heat-inactivated gingipains were still effective in inducing cytokine secretion.
- Macrophage stimulation with gingipains activated the p38α MAPK signaling pathway.
Takeaway
The bacteria that cause gum disease can make our immune cells send out signals that cause inflammation, which can hurt our gums.
Methodology
Human monocyte-derived macrophages were stimulated with Arg- and Lys-gingipain preparations, and cytokine secretion was measured.
Limitations
The study did not explore the long-term effects of gingipains on macrophage function.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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