Clinical Outcomes of Acute Pyelonephritis in Type 2 Diabetes Mellitus
Author Information
Author(s): Muacevic Alexander, Adler John R, Anandasekar Priyatharicini, Kaliaperumal Thirumal Valavan, Ramasubramanian Swaminathan, Mervin Edwin Fernando
Primary Institution: Stanley Medical College, Chennai, IND
Hypothesis
This study aims to evaluate the clinical and microbiological profiles, treatment outcomes, and complications of acute pyelonephritis in patients with type 2 DM.
Conclusion
Early diagnosis and aggressive management of EMPN in type 2 DM patients improve outcomes.
Supporting Evidence
- Escherichia coli was the most common organism isolated in 70 (68.6%) cases.
- Renal dysfunction was present in 67 (65.7%) patients, with a higher prevalence in EMPN (22, 100%) compared to NEMPN (45, 56.3%).
- Mortality was observed in three (3.9%) patients.
- 25 (24.5%) developed de novo or progressive chronic kidney disease.
Takeaway
This study looked at kidney infections in people with diabetes and found that early treatment helps them get better.
Methodology
A six-month prospective observational study was conducted with 102 hospitalized patients presenting with symptoms suggestive of acute pyelonephritis.
Potential Biases
Potential for selection bias as the study was conducted in a tertiary care center where more severe cases are likely to be referred.
Limitations
The study is limited by its single-center design and relatively small sample size, which may affect the generalizability of the findings.
Participant Demographics
The mean age was 55.2±10.9 years, with a female predominance of 63 (78.4%) participants.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 13.02-2339.49
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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