Effects of Anti-VEGF on Antibody Distribution in Mice
Author Information
Author(s): Boswell C. Andrew, Ferl Gregory Z., Mundo Eduardo E., Bumbaca Daniela, Schweiger Michelle G., Theil Frank-Peter, Fielder Paul J., Khawli Leslie A.
Primary Institution: Genentech Inc.
Hypothesis
What are the effects of anti-VEGF treatment on tissue vascular volumes and blood flow in mice?
Conclusion
Anti-VEGF treatment did not significantly affect the vascular volumes of tissues in mice, except for a borderline significant increase in hepatic blood flow.
Supporting Evidence
- Anti-VEGF had no significant effect on the fractional vascular volumes of any tissues studied.
- A borderline significant increase in mean hepatic blood flow was observed.
- Physiologically-based pharmacokinetic modeling showed substantial changes in predicted tissue exposure based on measured parameters.
Takeaway
The study looked at how a cancer treatment affects blood flow and tissue volume in mice, and found that it didn't change much at all.
Methodology
The study used radiopharmaceuticals to measure tissue vascular volumes and blood flow in mice treated with an anti-VEGF antibody.
Potential Biases
Potential bias in the interpretation of physiological parameters due to reliance on literature values for some measurements.
Limitations
The study's findings may not apply to all physiological conditions due to the specific model used and the limitations of the measurement techniques.
Participant Demographics
Female beige nude X-linked immunodeficient (XID) mice aged 6–8 weeks.
Statistical Information
P-Value
p=0.048
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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