Sucrose Counteracts the Anti-Inflammatory Effect of Fish Oil in Adipose Tissue and Increases Obesity Development in Mice
Author Information
Author(s): Ma Tao, Liaset Bjørn, Hao Qin, Petersen Rasmus Koefoed, Fjære Even, Ngo Ha Thi, Lillefosse Haldis Haukås, Ringholm Stine, Sonne Si Brask, Treebak Jonas Thue, Pilegaard Henriette, Frøyland Livar, Kristiansen Karsten, Madsen Lise
Primary Institution: Department of Biology, University of Copenhagen, Copenhagen, Denmark
Hypothesis
Does the amount of sucrose in the background diet influence the ability of n-3 PUFAs to protect against diet-induced obesity, adipose tissue inflammation, and glucose intolerance?
Conclusion
High levels of dietary sucrose counteract the anti-inflammatory effect of fish oil in adipose tissue and increase obesity development in mice.
Supporting Evidence
- Mice fed high sucrose diets became obese, while those on high protein diets remained lean.
- Sucrose intake increased insulin levels, which counteracted the benefits of fish oil.
- High protein diets led to increased energy expenditure compared to high sucrose diets.
- Sucrose diets resulted in higher expressions of inflammatory markers in adipose tissue.
- Fish oil did not prevent fat accumulation in the liver when combined with high sucrose.
Takeaway
If mice eat a lot of sugar, even healthy fish oil can't stop them from getting fat and inflamed.
Methodology
C57BL/6J mice were fed high fat diets with varying protein and sucrose content for 9 weeks to assess obesity and inflammation.
Potential Biases
Potential bias in dietary composition and the specific strains of mice used.
Limitations
The study was conducted on mice, which may not fully represent human responses to dietary changes.
Participant Demographics
Male C57BL/6J mice, approximately 8 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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