Prognostic Value of GEFs in Breast Cancer
Author Information
Author(s): Lane Jane, Martin Tracey A, Mansel Robert E, Jiang Wen G
Primary Institution: University Department of Surgery, Cardiff University School of Medicine
Hypothesis
This study investigates the expression of guanine nucleotide exchange factors Trio, Vav1, and TIAM-1 in human breast cancer and their impact on clinical outcomes.
Conclusion
High expression levels of Trio, Vav1, and TIAM-1 were found in breast tumors, particularly in those with poor prognosis, indicating their potential prognostic value.
Supporting Evidence
- Tumor tissue showed significantly higher levels of Trio compared to normal tissue (p = 0.013).
- Trio levels increased significantly in patients with a poor prognostic index (p = 0.04).
- TIAM-1 levels were significantly higher in tumor tissue from patients who died from breast cancer compared to those who survived (p = 0.04).
Takeaway
The study found that certain proteins in breast cancer cells are higher in tumors than in normal tissue, which might help doctors understand how serious the cancer is.
Methodology
The study analyzed fresh, frozen breast tumor tissue and normal tissue using quantitative PCR and immunostaining.
Participant Demographics
Patients with breast cancer, mean follow-up period of 72.2 months.
Statistical Information
P-Value
p = 0.013 for Trio, p = 0.04 for TIAM-1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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