CETP Gene Polymorphism and Atrial Fibrillation
Author Information
Author(s): Folkert W Asselbergs, Jason H Moore, Maarten P van den Berg, Eric B Rimm, Rudolf A de Boer, Robin P Dullaart, Gerjan Navis, Wiek H van Gilst
Primary Institution: University Medical Center Groningen
Hypothesis
Is there an association between CETP TaqIB polymorphism and susceptibility to atrial fibrillation?
Conclusion
CETP TaqIB polymorphism is significantly associated with the presence of atrial fibrillation in the context of other risk factors.
Supporting Evidence
- Subjects with AF had higher levels of C-reactive protein and urinary albumin excretion compared to controls.
- The TaqIB polymorphism of the CETP gene was significantly associated with AF.
- The best genotype-phenotype models included combinations of CETP TaqIB polymorphism with other risk factors.
Takeaway
This study found that a specific gene variation is linked to a common heart rhythm problem, especially when other health issues are present.
Methodology
A nested case-control study within the PREVEND cohort using logistic regression and multifactor-dimensionality reduction methods.
Limitations
The sample size is relatively small, and the CETP I405V polymorphism deviated from Hardy-Weinberg equilibrium in the control group.
Participant Demographics
Caucasian participants aged 28-75 from Groningen, Netherlands.
Statistical Information
P-Value
0.005
Confidence Interval
0.16–0.76
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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