TRALI Caused by Red Blood Cell Transfusion
Author Information
Author(s): H. Odent-Malaure, F. Quainon, P. Ruyer-Dumontier, S. Ducroz, P. Verdier, E. Voitellier, M.-F. Raynal, P. Fromont, J.-Y. Muller, D. Rebibo, L. Absi, O. Garraud
Primary Institution: Etablissement Francais du Sang Auvergne, Loire, France
Hypothesis
Can residual plasma anti-HLA antibodies in blood donors lead to transfusion-related acute lung injury (TRALI) in recipients?
Conclusion
The study presents two cases of TRALI caused by red blood cell transfusions, highlighting the role of anti-HLA antibodies in this serious complication.
Supporting Evidence
- TRALI is largely underestimated in frequency and diagnosis.
- Both cases involved multiparous female donors with strong anti-HLA antibodies.
- TRALI has been suspected in over 10% of transfusion-related deaths.
Takeaway
Sometimes, when people get blood transfusions, they can have a bad reaction called TRALI, which can happen if the blood has certain antibodies from the donor.
Methodology
The study involved case reports of two patients who developed TRALI after receiving packed red blood cells, with laboratory investigations to identify antibodies.
Potential Biases
Potential bias in donor selection and the underreporting of TRALI cases.
Limitations
The study is based on only two cases, which may not represent the broader population.
Participant Demographics
One male aged 78 and one female aged 70, both receiving red blood cell transfusions.
Digital Object Identifier (DOI)
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