Endometrial Stromal Sarcoma: A Study on Survival Factors
Author Information
Author(s): Chan J K, Kawar N M, Shin J Y, Osann K, Chen L-m, Powell C B, Kapp D S
Primary Institution: UCSF Helen Diller Family Comprehensive Cancer Center, University of California
Hypothesis
What are the independent prognostic factors for the survival of patients with endometrial stromal sarcoma?
Conclusion
Age, race, stage, and grade of disease are important independent prognostic factors for survival in patients with endometrial stromal sarcoma.
Supporting Evidence
- Patients with stage I–II disease had a 5-year disease-specific survival (DSS) of 89.3%.
- Blacks had a worse DSS compared to other races (62.5% vs 78.1%).
- Those who underwent primary hysterectomy had a significant benefit over those who did not (78.5% vs 42.4%).
- 5-year DSS for grades 1, 2, and 3 disease were 91.4%, 95.4%, and 42.1%, respectively.
Takeaway
This study looked at women with a rare type of uterine cancer and found that things like age and how advanced the cancer is can really affect how long they live.
Methodology
Data were abstracted from the SEER database and analyzed using Kaplan–Meier and Cox proportional hazards models.
Potential Biases
Previous studies were limited by small sample sizes and potential biases from single academic institutions.
Limitations
The study lacked information on surgeon specialty, residual disease status, hormone receptor status, and prior treatments.
Participant Demographics
Median age was 52 years, with a range from 17 to 96 years; 66.5% were White, 13.7% Black, 9.9% Hispanic, and 8.4% Asian.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI for age: 1.01–1.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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