(R)-1-[5-(2-Chloropropyl)indolin-1-yl]ethanone
2011
Study of a New Compound for Silodosin Synthesis
publication
Evidence: moderate
Author Information
Author(s): Yang Xue-Mei
Primary Institution: Guangdong Medical College
Hypothesis
The title compound was synthesized as an intermediate in the search for a new synthetic route to silodosin.
Conclusion
The synthesized compound exhibits a racemic crystal structure with specific hydrogen bonding interactions.
Supporting Evidence
- The compound was synthesized as an intermediate for silodosin.
- The crystal structure is stabilized by non-classical hydrogen bonds.
- The chloropropyl group is disordered over two positions.
Takeaway
Scientists made a new chemical compound that could help in creating a medicine called silodosin. They found that the compound has a special structure that helps it stay together.
Methodology
The compound was synthesized and analyzed using X-ray diffraction and spectroscopic methods.
Digital Object Identifier (DOI)
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