Genome-wide screening of copy number alterations and LOH events in renal cell carcinomas
Author Information
Author(s): Cifola Ingrid, Spinelli Roberta, Beltrame Luca, Peano Clelia, Fasoli Ester, Ferrero Stefano, Bosari Silvano, Signorini Stefano, Rocco Francesco, Perego Roberto, Proserpio Vanessa, Raimondo Francesca, Mocarelli Paolo, Battaglia Cristina
Primary Institution: University of Milan
Hypothesis
We investigated chromosomal regions and individual genes modulated in RCC pathology.
Conclusion
We identified specific genomic regions with concordant alterations in DNA and RNA profiles that may encode novel RCC biomarkers.
Supporting Evidence
- DNA copy number alterations were assessed at the genomic level in a set of 27 RCC samples.
- Regions of CN gain and loss were identified across all chromosomes.
- 71 differentially expressed genes were found in aberrant chromosomal regions.
Takeaway
Researchers looked at the DNA and RNA of kidney cancer samples to find changes that could help identify new cancer markers.
Methodology
The study used 100K SNP mapping arrays to analyze DNA and RNA profiles of RCC samples.
Limitations
The study is limited by its relatively small sample collection compared to larger datasets.
Participant Demographics
Patients diagnosed with clear cell renal carcinoma scheduled for surgical removal of the kidney.
Digital Object Identifier (DOI)
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