Surgical Treatment and Prognostic Analysis for Gastrointestinal Stromal Tumors of the Small Intestine
Author Information
Author(s): Wu Ting-Jung, Lee Li-Yu, Yeh Chun-Nan, Wu Pei-Yu, Chao Tzu-Chieh, Hwang Tsann-Long, Jan Yi-Yin, Chen Miin-Fu
Primary Institution: Chang Gung Memorial Hospital
Hypothesis
What are the predictors for long-term disease-free survival and overall survival in small intestine GIST patients?
Conclusion
Tumors with low cellularity, low mitotic count, and low Ki-67 index predict a more favorable disease-free survival for small intestine GIST patients undergoing curative resection.
Supporting Evidence
- 85 patients underwent curative resection, with a 5-year disease-free survival rate of 43.7%.
- 44 out of 85 patients who underwent curative resection developed disease recurrence.
- High tumor cellularity, mitotic count >5/50 HPF, and Ki-67 index ≧10% were independent factors associated with worse disease-free survival.
Takeaway
This study looked at patients with a type of tumor in the intestines and found that certain features of the tumors can help doctors predict how well patients will do after surgery.
Methodology
The study reviewed clinicopathologic and follow-up records of 100 small intestine GIST patients treated at Chung Gung Memorial Hospital from 1983 to 2002, using univariate and multivariate analyses.
Potential Biases
Potential bias due to the retrospective nature of the study and the exclusion of patients with other malignancies.
Limitations
The study is retrospective and may have selection bias due to the exclusion of certain patients.
Participant Demographics
52 men and 48 women, ages ranged from 27 to 82 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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