The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas
Author Information
Author(s): Dondi Francesco, Gazzilli Maria, Viganò Gian Luca, Pisani Antonio Rosario, Ferrari Cristina, Rubini Giuseppe, Bertagna Francesco
Primary Institution: Nuclear Medicine, Università Degli Studi di Brescia and ASST Spedali Civili di Brescia
Hypothesis
The aim of this paper was to review the available scientific literature focusing on the role of 11C-Methionine PET imaging in the assessment of lymphomas.
Conclusion
Even with heterogeneous evidence, a possible role for 11C-MET PET imaging in the assessment of lymphomas affecting both the whole body and the central nervous system was underlined.
Supporting Evidence
- Eighteen studies were included in the systematic review.
- The main fields of application of this imaging modality were the evaluation of disease, therapy response assessment, prognostic evaluation and differential diagnosis.
- Compared to 18F-FDG imaging, in general, similar results have been reported between the two modalities.
Takeaway
This study looked at how a special type of imaging called 11C-MET PET can help doctors see and understand lymphomas better, especially in tricky areas like the brain.
Methodology
A wide literature search of the PubMed/MEDLINE, Scopus and Cochrane Library databases was conducted to find relevant published articles investigating the role of 11C-MET in the assessment of lymphomas.
Potential Biases
The quality assessment using QUADAS-2 evaluation underlined the presence of low risk of bias in most of the domains for all the studies included in the review.
Limitations
Most studies included were characterized by small and heterogeneous cohorts, and many had a retrospective design.
Digital Object Identifier (DOI)
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