Interactions Between Genetic Factors and Smoking in Colorectal Cancer
Author Information
Author(s): Fan Chunhong, Jin Mingjuan, Chen Kun, Zhang Yongjing, Zhang Shuangshuang, Liu Bing
Primary Institution: Department of Epidemiology & Health Statistics, School of Public Health, Zhejiang University
Hypothesis
The study aims to measure the interactions between common polymorphisms of metabolic enzymes and cigarette smoking in colorectal cancer.
Conclusion
The interaction between polymorphisms in CYP1B1 1294G and SULT1A1*2 may significantly influence colorectal cancer risk in the Chinese population.
Supporting Evidence
- The interaction odds ratio for the gene-gene interaction between CYP1B1 1294G and SULT1A1 638A allele was 2.68.
- An interaction existed between cigarette smoking and the CYP1B1 1294G allele for colorectal cancer.
- The odds ratio for the interaction of CYP1B1 1294G and smoking history > 35 pack-years was 3.47.
Takeaway
This study found that certain genes and smoking habits can work together to increase the risk of colorectal cancer.
Methodology
A case-only design was used with unconditional logistic regression analysis adjusting for age, gender, alcohol consumption, and cigarette smoking.
Potential Biases
Independence between genotypes and environment exposure must be assumed for the case-only design.
Limitations
Selection bias might occur as all patients were cancer survivors at the time of analysis.
Participant Demographics
Participants were 207 patients with sporadic colorectal cancer, predominantly ethnic Han Chinese, with a mean age of 65.82 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 1.01–6.72
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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