Decellularization of fish tissues for tissue engineering and regenerative medicine applications
2025

Decellularization of Fish Tissues for Tissue Engineering

publication Evidence: moderate

Author Information

Author(s): Wenhui Chen, Mengshi Chen, Siyi Chen, Siran Wang, Zijin Huang, Lining Zhang, Jiaming Wu, Weijie Peng, Huaqiong Li, Feng Wen

Primary Institution: Zhejiang Engineering Research Centre for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences

Hypothesis

The decellularization of fish tissues can provide a viable source of acellular scaffolds for tissue engineering and regenerative medicine applications.

Conclusion

Decellularized fish tissues exhibit good biocompatibility and potential for various tissue engineering applications.

Supporting Evidence

  • Decellularized fish tissues retain the structure and bioactive components of their native tissues.
  • Fish tissues are less likely to transmit zoonotic diseases compared to mammalian tissues.
  • Decellularization methods can be optimized to enhance the mechanical properties and biocompatibility of the resulting scaffolds.
  • Commercial products derived from decellularized fish tissues have been developed for various medical applications.

Takeaway

Scientists are using fish parts to make materials that can help heal injuries because fish tissues are safe and work well in the body.

Methodology

The review discusses various decellularization methods including physical, chemical, and enzymatic techniques used to prepare acellular fish tissues.

Limitations

The review does not provide specific quantitative data on the effectiveness of the decellularization methods.

Digital Object Identifier (DOI)

10.1093/rb/rbae138

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