CDC25A and CDC25B in Oesophageal Cancer
Author Information
Author(s): Nishioka K, Doki Y, Shiozaki H, Yamamoto H, Tamura S, Yasuda T, Fujiwara Y, Yano M, Miyata H, Kishi K, Nakagawa H, Shamma A, Monden M
Primary Institution: Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University
Hypothesis
CDC25A and CDC25B expressions are associated with the prognosis of squamous cell carcinoma of the oesophagus.
Conclusion
CDC25A expression is a significant prognostic factor for patients with squamous cell carcinoma of the oesophagus.
Supporting Evidence
- CDC25A and CDC25B were strongly expressed in the cytoplasm of cancer cells.
- CDC25A (+) patients had significantly poorer postoperative survival compared to CDC25A (–) patients.
- Multivariate analysis revealed CDC25A status as an independent significant prognostic factor.
Takeaway
This study found that a protein called CDC25A can help predict how well patients with a certain type of throat cancer will do after treatment.
Methodology
Expressions of CDC25A and CDC25B were analyzed using immunohistochemistry, western blot, and RT-PCR.
Participant Demographics
Patients with squamous cell carcinoma of the oesophagus.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website