Nicotinamide Riboside Helps Protect Aging Mice from Brain Damage
Author Information
Author(s): Enterria-Morales Daniel, Gonzalez Anais Claire, Jallorina Bianca, Martinez Adrian, Doan Andrew, Karve Aadit, Joya Mikaela, Shtrahman Matthew
Primary Institution: University of California San Diego
Hypothesis
Boosting cellular NAD+ levels may help neurons maintain healthy function and slow neurodegeneration.
Conclusion
Nicotinamide Riboside supplementation can partially prevent neurodegeneration in aged mice by reducing inflammation.
Supporting Evidence
- Nicotinamide Riboside was administered for three weeks before viral injection.
- The study found reduced activation of microglia and astrocytes in the hippocampus.
- NR supplementation partially rescued neurodegeneration in the CA3 region.
Takeaway
Giving older mice a special supplement can help their brains stay healthier and fight off damage.
Methodology
Nicotinamide Riboside was given in drinking water for three weeks before a viral injection, and effects were measured after 12 weeks.
Limitations
Further mechanistic studies are required to understand the cellular pathways involved.
Participant Demographics
C57BL/6J wild-type mice, 18 months old.
Digital Object Identifier (DOI)
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