Quantifying the Diagnostic Odyssey Burden Among Persons with Inborn Errors of Immunity
2025

Understanding Health Status in Patients with Inborn Errors of Immunity

Sample size: 1139 publication 10 minutes Evidence: high

Author Information

Author(s): Sarina Nikzad, Rebekah Johnson, Christopher Scalchunes, Nick Rider

Primary Institution: Immune Deficiency Foundation

Hypothesis

What factors are related to patient-reported health status in individuals with inborn errors of immunity?

Conclusion

Early diagnosis and fewer physicians seen are associated with better health outcomes for patients with inborn errors of immunity.

Supporting Evidence

  • Patients diagnosed before age 12 had better health scores.
  • Patients diagnosed within 10 years of symptom onset reported improved health.
  • Seeing fewer physicians correlated with better health outcomes.

Takeaway

If kids with immune problems get diagnosed early and see fewer doctors, they feel healthier.

Methodology

Data from the Immune Deficiency Foundation 2017 National Patient Survey was analyzed using t-tests and ANOVA to assess health status.

Potential Biases

Selection bias, recall bias, and response bias may affect the results.

Limitations

The sample may not represent the general population and is subject to various biases.

Participant Demographics

{"average_age":39.55,"male_percentage":24,"female_percentage":73,"race_distribution":{"white":94,"black":0.5,"latin":2,"asian":1,"other":0.5}}

Statistical Information

P-Value

p<0.0001

Confidence Interval

95% Confidence interval

Statistical Significance

p<0.0001

Digital Object Identifier (DOI)

10.1007/s10875-024-01855-x

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