miRNATissueAtlas 2025: Update on Human and Mouse Non-Coding RNA Tissue Atlas
Author Information
Author(s): Rishik Shusruto, Hirsch Pascal, Grandke Friederike, Fehlmann Tobias, Keller Andreas
Primary Institution: Saarland University
Conclusion
The updated miRNATissueAtlas 2025 provides a comprehensive resource of miRNA expression data from 61,593 samples across various tissues in humans and mice.
Supporting Evidence
- The miRNATissueAtlas 2025 includes data from 799 billion reads.
- The number of tissues analyzed increased from 54 to 373.
- 35 organs are common between humans and mice, allowing for cross-species comparisons.
- New tissue specificity index calculations were introduced to enhance data analysis.
- The dataset is one of the largest collections of harmonized non-coding RNA samples.
Takeaway
This study created a big library of tiny molecules called miRNAs that help control how genes work in different parts of the body for humans and mice.
Methodology
The study used high-quality sequencing data from public databases, harmonized tissue labels, and calculated tissue specificity indices for various non-coding RNAs.
Potential Biases
Potential biases may arise from different sequencing protocols and the focus on only two species, limiting broader insights.
Limitations
The dataset may not fully represent all experimental conditions and is unbalanced in terms of sample origin, which could affect analysis results.
Participant Demographics
The study includes samples from both Homo sapiens and Mus musculus, with a focus on various tissues and cell lines.
Digital Object Identifier (DOI)
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