Physical Activity Levels in Mitochondrial Disease
Author Information
Author(s): Apabhai Shehnaz, Gorman Grainne S., Sutton Laura, Elson Joanna L., Plötz Thomas, Turnbull Douglass M., Trenell Michael I.
Primary Institution: Newcastle University
Hypothesis
What is the level of habitual physical activity in people with mitochondrial disease and how does it relate to their clinical phenotype?
Conclusion
Low levels of physical activity are common in mitochondrial disease patients, which may increase their risk of obesity and other health issues.
Supporting Evidence
- Patients with mitochondrial disease had significantly lower levels of physical activity compared to controls.
- 78% of the mitochondrial disease cohort did not achieve 10,000 steps per day.
- 48% of the patient group were classified as overweight or obese.
Takeaway
People with mitochondrial disease don't move around much, which can make them unhealthy and overweight.
Methodology
Habitual physical activity, genotype, and clinical presentations were assessed in 100 patients with mitochondrial disease and compared to a matched control group.
Limitations
The study did not include exercise-based interventions during the trial.
Participant Demographics
Participants were over 18 years of age, with a mix of genotypes and clinical presentations.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI −0.33, −0.63
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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