Breast cancer and NSAID use: a meta-analysis
2001
Breast Cancer and NSAID Use: A Meta-Analysis
publication
Evidence: moderate
Author Information
Author(s): Khuder S A, Mutgi A B
Primary Institution: Medical College of Ohio
Hypothesis
Do non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of breast cancer?
Conclusion
NSAID use may be associated with a small decrease in the risk of breast cancer.
Supporting Evidence
- The combined estimate of relative risk was 0.82.
- The combined estimate for cohort studies was 0.78.
- The combined estimate for case-control studies was 0.87.
Takeaway
Taking certain pain relievers called NSAIDs might help lower the chances of getting breast cancer.
Methodology
This meta-analysis examined 6 cohort studies and 8 case-control studies on NSAID use and breast cancer.
Limitations
The available data are insufficient to estimate the dose–response effect for duration and frequency of NSAID use.
Participant Demographics
Studies included females with varying case numbers.
Statistical Information
Confidence Interval
95% CI = 0.75–0.89
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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