Oseltamivir-Resistant H1N1 in a Child in Israel
Author Information
Author(s): Zonis Zeev, Engelhard Dan, Hindiyeh Musa, Ram Daniela, Mandelboim Michal, Mendelson Ella, Glikman Daniel
Primary Institution: Western Galilee Hospital, Nahariya, Israel
Hypothesis
How can a healthy child acquire oseltamivir-resistant H1N1 without prior exposure to the drug?
Conclusion
A healthy 2-year-old boy in Israel developed oseltamivir-resistant H1N1 without prior antiviral treatment, suggesting community transmission of resistant strains.
Supporting Evidence
- Only 264 cases of oseltamivir-resistant H1N1 had been reported globally by March 2010.
- The patient had not received prior oseltamivir treatment or prophylaxis.
- Resistance was confirmed through laboratory testing showing the H275Y mutation.
Takeaway
A 2-year-old boy got a flu that was resistant to a common medicine, even though he never took that medicine before. This shows that the resistant flu can spread in the community.
Methodology
The case study involved clinical observation and laboratory testing for H1N1 and oseltamivir resistance.
Limitations
The study is based on a single case, limiting the generalizability of the findings.
Participant Demographics
The participant was a 2-year-old boy from Israel.
Digital Object Identifier (DOI)
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