Glycemic Index and Glycemic Load's Impact on C-Reactive Protein and Type 2 Diabetes
Author Information
Author(s): Geertruida J. van Woudenbergh, Anneleen Kuijsten, Eric J. G. Sijbrands, Albert Hofman, Jacqueline C. M. Witteman, Edith J. M. Feskens
Primary Institution: Wageningen University
Hypothesis
Is the Glycemic Index (GI) or Glycemic Load (GL) of a diet associated with C-reactive Protein (CRP) and the risk of type 2 diabetes?
Conclusion
GL was positively associated with CRP concentrations, but neither GI nor GL was associated with the risk of type 2 diabetes.
Supporting Evidence
- GL was associated with a 12% higher CRP concentration at baseline.
- GI was not associated with CRP or diabetes risk.
- 456 diabetes cases were confirmed during the follow-up.
- The study included a large population with a high response rate.
Takeaway
Eating foods with a high Glycemic Load might increase inflammation in the body, but it doesn't seem to affect the chances of getting diabetes.
Methodology
The study analyzed dietary data from a food-frequency questionnaire and monitored diabetes incidence over a median follow-up of 12.4 years.
Limitations
The study's food-frequency questionnaire may not have captured the full range of GI values, potentially affecting the results.
Participant Demographics
Participants were Dutch adults aged 55 and older.
Statistical Information
P-Value
P = .01 for GL association with CRP
Confidence Interval
[95%CI 0.75, 1.21] for GI and [95%CI 0.74, 1.36] for GL
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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