Prognostic Factors in Small Bowel Adenocarcinoma
Author Information
Author(s): Chaiyasate Kongkrit, Jain Akhilesh K, Cheung Laurence Y, Jacobs Michael J, Mittal Vijay K
Primary Institution: Providence Hospital and Medical Centers
Hypothesis
What factors influence long-term survival in patients with adenocarcinoma of the small bowel?
Conclusion
Tumor grade, stage at presentation, lymph nodal metastasis, and resection margins are significant predictors of survival in small bowel adenocarcinoma.
Supporting Evidence
- Only 48% of patients had an accurate preoperative diagnosis.
- The cumulative five-year survival was 30%.
- None of the patients presented in stage 1.
- Patients with well-differentiated tumors had a median survival of 66 months.
Takeaway
This study looked at patients with a rare type of cancer in the small intestine and found that how advanced the cancer is when diagnosed and how well it can be surgically removed are really important for survival.
Methodology
The study reviewed medical records of 27 patients treated for small bowel adenocarcinoma from 1990 to 2003, analyzing survival and prognostic factors using SPSS software.
Limitations
The study is limited by its retrospective design and small sample size.
Participant Demographics
The cohort included 9 males and 18 females with a median age of 62 years.
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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