Genetic Variant EDN1 Lys198Asn and Diabetic Retinopathy
Author Information
Author(s): Li Haitao, Louey Janice W.C., Choy Kwong Wai, Liu David T.L., Chan Wai Man, Chan Yiu Man, Fung Nicholas S.K., Fan Bao Jian, Baum Larry, Chan Juliana C.N., Lam Dennis S.C., Pang Chi Pui
Primary Institution: The Chinese University of Hong Kong
Hypothesis
Genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR).
Conclusion
The Asn/Asn genotype of EDN1 was associated with a reduced risk of DR and with delayed onset of type 2 diabetes.
Supporting Evidence
- The Asn/Asn genotype was found more frequently in controls than in DR patients.
- The Asn allele was more common in controls than in DR patients.
- The Asn/Asn genotype was significantly associated with reduced risk of DR.
Takeaway
People with a specific genetic variant (Asn/Asn) are less likely to develop diabetic eye problems and tend to get diabetes later in life.
Methodology
A case-control study was performed to study the genetic association between DR and polymorphic variants in a Chinese population with type 2 diabetes.
Limitations
The study focused only on a Chinese population, which may limit the generalizability of the findings.
Participant Demographics
Chinese population with type 2 diabetes mellitus.
Statistical Information
P-Value
p=0.0002
Confidence Interval
95% CI: 0.07-0.53
Statistical Significance
p<0.05
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