Effects of hypoxia on uteroplacental and fetoplacental vascular function during pregnancy
2024

Effects of Hypoxia on Blood Flow in Pregnancy

publication Evidence: moderate

Author Information

Author(s): Arenas Germán A., Lorca Ramón A.

Primary Institution: University of Colorado Anschutz Medical Campus

Hypothesis

Chronic hypoxia negatively affects uteroplacental and fetoplacental vascular function during pregnancy.

Conclusion

Chronic hypoxia can lead to complications in pregnancy, such as fetal growth restriction and preeclampsia, by impairing vascular adaptations.

Supporting Evidence

  • Chronic hypoxia has detrimental effects on vascular adaptations to pregnancy.
  • Impaired vascular adaptations are associated with complications like fetal growth restriction and preeclampsia.
  • Evidence suggests that hypoxia-induced alterations affect pregnancy outcomes in both humans and animal models.

Takeaway

When pregnant women don't get enough oxygen, it can hurt the blood flow to the baby, making it harder for the baby to grow healthy.

Methodology

This review discusses the effects of hypoxia on blood flow and vascular function during pregnancy, supported by evidence from human and animal studies.

Limitations

The review primarily focuses on existing literature and may not cover all recent findings or clinical trials.

Digital Object Identifier (DOI)

10.3389/fphys.2024.1490154

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