Lymph Nodes in Transitional Cell Carcinoma of the Kidney and Ureter
Author Information
Author(s): Shilajit D. Kundu, Scott E. Eggener
Primary Institution: Memorial Sloan-Kettering Cancer Center
Conclusion
Lymph node involvement in transitional cell carcinoma of the kidney and ureter is associated with poor prognosis, but lymphadenectomy may provide therapeutic benefits.
Supporting Evidence
- Up to 30% of patients with UT-TCC have regional nodal involvement.
- The five-year cancer-specific survival among patients with lymph node involvement varies widely and ranges from 0–39%.
- Stage and grade of UT-TCC are independently associated with recurrence and survival.
Takeaway
This study looks at how cancer in the kidney and ureter can spread to nearby lymph nodes and how removing those nodes might help patients live longer.
Methodology
This is a review article summarizing existing literature on lymph node involvement and management in transitional cell carcinoma.
Potential Biases
There is a risk of selection bias due to nonuniform application of lymphadenectomy and confounding factors affecting survival outcomes.
Limitations
The study is limited by the retrospective nature of the included studies and the variability in lymphadenectomy practices.
Digital Object Identifier (DOI)
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