Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease
Author Information
Author(s): Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein, Peter R Mertens
Primary Institution: Department of Medicine III, University Hospital Aachen, RWTH-Aachen, Germany
Hypothesis
The clinical and diagnostic value of YB-1 protein fragment p18 (YB-1/p18) detection in blood for malignant diseases was tested.
Conclusion
Plasma YB-1/p18 can identify patients with malignancies, independent of acute inflammation, renal impairment or liver dysfunction.
Supporting Evidence
- YB-1/p18 was detected in 11 out of 25 patients with hepatocellular carcinoma.
- YB-1/p18 was found in 16 out of 20 patients with advanced carcinomas.
- 20 out of 111 patients with chronic liver disease tested positive for YB-1/p18.
Takeaway
Researchers found a protein fragment in the blood that can help spot cancers in people with liver disease, even if they don't have other symptoms.
Methodology
Immunoblotting was used to detect YB-1/p18 in plasma samples from various patient cohorts.
Limitations
The study had a relatively small cohort size and a short follow-up period for high-risk patients.
Participant Demographics
111 patients with chronic liver diseases (66 male, 45 female, median age 46 years; range 18-70 years).
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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