FurinDB: A Database of Furin Cleavage Site Motifs and Associated Drugs
Author Information
Author(s): Tian Sun, Huang Qingsheng, Fang Ying, Wu Jianhua
Primary Institution: South China University of Technology
Hypothesis
The study aims to develop a comprehensive database of furin cleavage sites and their associated drugs to facilitate research in molecular biology.
Conclusion
FurinDB is a valuable resource for studying furin cleavage sites and their roles in various human diseases.
Supporting Evidence
- The database includes 126 experimentally verified furin cleavage sites.
- It contains information about substrates from mammals, bacteria, and viruses.
- FurinDB aims to elucidate the molecular mechanisms of furin cleavage associated with human diseases.
Takeaway
FurinDB is like a big library that helps scientists find information about how certain proteins are cut and what drugs can target them.
Methodology
The database was developed using PHP 5 and MySQL, collecting data from peer-reviewed literature.
Limitations
The database currently contains data from only three species and may not include all known furin substrates.
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