Blood Biomarkers and Muscle Strength in Older Adults
Author Information
Author(s): Ornago Alice, Pinardi Elena, Grande Giulia, Valletta Martina, Calderón-Larrañaga Amaia, Fredolini Claudia, Bellelli Giuseppe, Vetrano Davide Liborio
Primary Institution: Karolinska Institutet
Hypothesis
This study aimed to investigate the association between a panel of Alzheimer’s disease (AD) blood biomarkers and longitudinal trajectories of muscle strength.
Conclusion
Several blood biomarkers implicated in Alzheimer's disease are associated with distinct trajectories of muscle strength, and cognitive function influences this association.
Supporting Evidence
- Higher baseline levels of p-Tau181 were associated with accelerated worsening of the chair stand test.
- Higher baseline levels of NfL were associated with accelerated worsening of the chair stand test.
- Higher baseline levels of GFAP were associated with accelerated worsening of the chair stand test.
- Higher baseline levels of p-Tau181 were associated with a faster decline in the grip strength test.
- Higher baseline levels of NfL were associated with a faster decline in the grip strength test.
Takeaway
The study found that certain blood markers related to Alzheimer's can help predict how muscle strength changes as people get older.
Methodology
This was a 12-year population-based cohort study measuring muscle strength through grip strength and chair stand tests, with blood biomarkers assessed using Quanterix Single Molecule Arrays.
Participant Demographics
Dementia-free older adults from the Swedish National study on Aging and Care in Kungsholmen.
Statistical Information
Confidence Interval
95%CI 0.72;1.16 for p-Tau181, 95%CI 0.59;0.99 for NfL, 95% CI 0.22;0.54 for GFAP.
Digital Object Identifier (DOI)
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