Spirulina Algal Extract as an Antibacterial Agent Against Drug-Resistant Bacteria
Author Information
Author(s): Selim Mohamed I., El-banna Tarek, Sonbol Fatma, Negm Walaa A., Elekhnawy Engy
Primary Institution: Tanta University
Hypothesis
Can spirulina algal extract effectively combat carbapenem-resistant Klebsiella pneumoniae?
Conclusion
The study found that spirulina algal extract has promising antibacterial and antibiofilm activities against carbapenem-resistant Klebsiella pneumoniae.
Supporting Evidence
- Spirulina extract showed minimum inhibitory concentrations ranging from 500 to 1000 µg/mL against K. pneumoniae.
- Histopathological analysis indicated improvement in lung architecture in treated mice.
- Spirulina extract inhibited biofilm formation in 68.75% of the tested isolates.
Takeaway
Spirulina, a type of green algae, can help fight off bad bacteria that don't respond to regular medicines.
Methodology
The study involved in vitro and in vivo testing of spirulina extract against K. pneumoniae, including antibiotic susceptibility testing and histopathological analysis.
Participant Demographics
30 clinical isolates from various samples including blood, urine, and sputum.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website