Indole-3-carbinol's Effects on Adult T-cell Leukemia
Author Information
Author(s): Machijima Yoshiaki, Ishikawa Chie, Sawada Shigeki, Okudaira Taeko, Uchihara Jun-nosuke, Tanaka Yuetsu, Taira Naoya, Mori Naoki
Primary Institution: University of the Ryukyus
Hypothesis
The study aims to determine the potential anti-ATLL effects of indole-3-carbinol (I3C) both in vitro and in vivo.
Conclusion
I3C could be a useful chemotherapeutic agent for patients with ATLL.
Supporting Evidence
- I3C inhibited cell viability of HTLV-1-infected T-cell lines in a dose-dependent manner.
- I3C did not affect uninfected T-cell lines or normal peripheral blood mononuclear cells.
- I3C induced apoptosis in HTLV-1-infected T-cell lines.
- I3C treatment resulted in significant tumor growth inhibition in mice.
- I3C suppressed NF-κB and AP-1 activation, which are crucial for cell survival.
Takeaway
Indole-3-carbinol, a compound found in vegetables, can help fight a type of blood cancer called adult T-cell leukemia by making the cancer cells die.
Methodology
The study involved in vitro assays on T-cell lines and in vivo experiments on mice to assess the effects of I3C on cell viability and apoptosis.
Limitations
The study primarily focuses on preclinical data, and the effects in humans remain to be fully established.
Participant Demographics
Eight patients with acute type ATLL were included in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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