Quality of Randomised Controlled Trials in China
Author Information
Author(s): Zhang Dalu, Yin Peng, Freemantle Nick, Jordan Rachel, Zhong Nanshan, Cheng KK
Primary Institution: University of Birmingham
Hypothesis
What is the quality of randomised controlled trials conducted in China?
Conclusion
The reporting of RCTs in China needs significant improvement to meet international standards.
Supporting Evidence
- 64.8% of trials failed to report methods of randomization.
- 82.4% did not mention blinding of participants or investigators.
- Less than 11% of trials mentioned ethical approval.
- Only 18% adequately discussed informed consent.
- 44% of trials reported a zero dropout rate.
Takeaway
This study looked at clinical trials in China and found that many didn't follow important rules for reporting their methods, which means we can't trust their results.
Methodology
A systematic review and critical appraisal of RCTs published in 2004 was conducted using PubMed and the Journal Series of the Chinese Medical Association.
Potential Biases
Poor reporting may lead to selection bias and undermine the validity of the trials.
Limitations
The study may have missed relevant trials not included in the databases used for the search.
Participant Demographics
The trials included Chinese citizens.
Digital Object Identifier (DOI)
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