The Influence of Nordic Walking Training on the Serum Levels of Sirtuins, FOXO3a, and Vitamin D Metabolites in Patients with Multiple Myeloma
2024

Nordic Walking Training and Vitamin D in Multiple Myeloma Patients

Sample size: 30 publication Evidence: moderate

Author Information

Author(s): Czerwińska-Ledwig Olga, Żychowska Małgorzata, Jurczyszyn Artur, Kryst Joanna, Dzidek Adrianna, Zuziak Roxana, Jurczyszyn Anna, Piotrowska Anna

Primary Institution: Institute for Basic Sciences, Faculty of Physiotherapy, University of Physical Education, Krakow, Poland

Hypothesis

The training intervention may induce changes in the examined sirtuins and vitamin D metabolites.

Conclusion

The 6-week Nordic walking training cycle positively affected the level of vitamin 25(OH)D3 but did not influence the rest of the biochemical parameters studied.

Supporting Evidence

  • The training group showed a significant increase in physical activity levels.
  • Vitamin 25(OH)D3 levels increased significantly in the training group over time.
  • No significant changes were observed in the serum levels of sirtuins and FOXO3a.

Takeaway

Patients with multiple myeloma who did Nordic walking for six weeks had higher vitamin D levels, but it didn't change other important proteins.

Methodology

30 patients were divided into a training group and a control group, with blood samples taken at multiple time points to assess biochemical markers.

Limitations

The study had a small sample size.

Participant Demographics

Mean age of participants was 62.3 years in the training group and 63.6 years in the control group.

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.3390/curroncol31120587

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