A Rare Case of CLL Transforming Into WM During Ibrutinib Therapy
Author Information
Author(s): Muacevic Alexander, Adler John R, Samsuddoha Kazi, Homsy Sylvester, Preet Mohan, Naher Kamrun
Primary Institution: State University of New York Downstate Medical Center, Brooklyn, USA
Hypothesis
Can chronic lymphocytic leukemia (CLL) transform into Waldenström macroglobulinemia (WM) during treatment with ibrutinib?
Conclusion
This case highlights the rare transformation of CLL into WM during ibrutinib therapy, emphasizing the need for further investigation into the underlying pathology.
Supporting Evidence
- CLL can transform into WM, which is a rare occurrence.
- The patient had a MYD88 mutation confirming the diagnosis of WM.
- Symptoms of WM include anemia and splenomegaly, which were present in the patient.
- Immunophenotypic markers were used to diagnose the transformation.
Takeaway
Sometimes, a type of blood cancer called CLL can change into another type called WM while being treated. This is very rare and needs more study.
Methodology
Case report detailing the clinical progression and diagnostic findings of a patient with CLL transforming into WM.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
50-year-old man with a history of HIV and other medical conditions.
Digital Object Identifier (DOI)
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