Using Tamarix ericoides Bark to Prevent Catheter Infections
Author Information
Author(s): Karrar Alsharif Mohammed H., Poyil Muhammad Musthafa, Bin Dayel Salman, Alqahtani Mohammed Saad, Albadrani Ahmed Abdullah, Omar Zainab Mohammed M., Arafah Abdullah MR., Alarabi Tarig Gasim Mohamed, Fayyad Reda M., Abd El-Lateef Abd El-Lateef Saeed, Chen Shun-Hua, Chen Po-Jen, Chang Yu-Chia
Primary Institution: Prince Sattam bin Abdulaziz University
Hypothesis
Can the bark of Tamarix ericoides effectively prevent catheter-associated urinary tract infections (CAUTIs) caused by Enterococcus faecalis?
Conclusion
The Tamarix ericoides bark extract showed significant antibacterial and antibiofilm activity against E. faecalis, suggesting its potential as a catheter coating to prevent CAUTIs.
Supporting Evidence
- The extract reduced E. faecalis mature biofilms by 75%, 82%, and 83% at different concentrations.
- The minimum inhibitory concentration (MIC) of the extract was found to be 2 mg/mL.
- 80% of E. faecalis cells were dead on the extract-coated catheter tube.
- SEM analysis showed extensive damage to E. faecalis cells after treatment with the extract.
Takeaway
This study found that a natural plant extract can help stop infections from catheters by killing bacteria and preventing them from sticking.
Methodology
The study used various methods including well diffusion, microdilution, time-kill assays, and crystal violet assays to evaluate the antibacterial and antibiofilm activities of the Tamarix ericoides bark extract.
Limitations
Further in vivo studies are needed to confirm the effectiveness of the extract as a catheter coating agent.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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