Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis
2000
HGF and c-met in Intestinal Recovery After Methotrexate
publication
Evidence: moderate
Author Information
Author(s): Xian C J, Couper R, Howarth G S, Read L C, Kallincos N C
Primary Institution: Child Health Research Institute, University of Adelaide
Hypothesis
The study investigates the role of HGF and c-met in intestinal repair following methotrexate-induced mucositis.
Conclusion
HGF and c-met are up-regulated during the recovery of the intestine after methotrexate treatment, indicating their role in tissue repair.
Supporting Evidence
- HGF and c-met expression was up-regulated between days 4 and 7 after methotrexate injection.
- Histological analysis showed maximal damage on day 5, with recovery starting on day 6.
- Crypt cell proliferation decreased dramatically on day 3 and was up-regulated on days 5 and 6.
Takeaway
When cancer patients get treatment, their intestines can get hurt, but certain proteins help them heal afterward.
Methodology
The study used a rat model to analyze the expression of HGF and c-met during recovery from methotrexate-induced intestinal damage.
Participant Demographics
Rat model used for the study.
Digital Object Identifier (DOI)
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