A Novel Motif Identified in Dependence Receptors DART Motif
2007
Identifying a New Motif in Dependence Receptors
Sample size: 32
publication
Evidence: moderate
Author Information
Author(s): del Rio Gabriel, Kane Darci J., Ball Keith D., Bredesen Dale E.
Primary Institution: Buck Institute for Age Research
Hypothesis
Do dependence receptors display a common motif that has gone undetected?
Conclusion
The study identified a novel DART motif in dependence receptors, suggesting a potential role in apoptosis and protein interactions.
Supporting Evidence
- The DART motif was found in 25 out of 3,465 human transmembrane proteins.
- The motif is characterized by a high percentage of valine residues.
- At least four proteins with the DART motif undergo regulated intramembrane proteolysis.
Takeaway
The researchers found a special pattern in certain proteins that might help them understand how these proteins work together in the body.
Methodology
The study used MEME and MAST software to identify and analyze motifs in transmembrane proteins.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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