Eicosanoid Receptors and Eosinophilic Inflammation in Chronic Rhinosinusitis
Author Information
Author(s): Claudina Angela Pérez-Novo, Cindy Claeys, Paul Van Cauwenberge, Claus Bachert
Primary Institution: Ghent University Hospital
Hypothesis
Eicosanoid receptor expression is altered in chronic rhinosinusitis patients with and without nasal polyposis in absence of aspirin intolerance and these changes may be related to eosinophilic inflammation.
Conclusion
CysLTs receptors are up-regulated in nasal polyp tissue and their expression correlates with eosinophilic inflammation.
Supporting Evidence
- CysLT1 mRNA expression was significantly increased in CRS-NP compared to CRS and controls.
- PGE2 protein concentrations were down-regulated in CRS-NP tissue vs. CRS and controls.
- Levels of eosinophilic inflammation markers were significantly higher in CRS-NP compared to CRS and controls.
Takeaway
This study found that certain receptors related to inflammation are more active in patients with nasal polyps, which might explain why they have more inflammation.
Methodology
Nasal tissue samples were collected from patients with chronic rhinosinusitis and analyzed for eicosanoid receptor expression using real-time PCR and ELISA.
Limitations
The study is descriptive and preliminary, lacking protein regulation and functional studies.
Participant Demographics
Patients included 13 with nasal polyps (10 males, 3 females) and 11 without (8 males, 3 females), ages 21-54.
Statistical Information
P-Value
p<0.01 for LTC4/D4/E4 levels, p=0.001 for PGE2 concentrations in CRS-NP.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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