The Role of CCDC8 in Bladder Cancer Prognosis
Author Information
Author(s): Zhao Xiaojie, Yu Xin, Li Wenge, Wang Lei, Weng Xiaodong, Liu Cheng, Liu Xiuheng
Primary Institution: Renmin Hospital of Wuhan University
Hypothesis
What is the prognostic significance of CCDC8 in bladder cancer?
Conclusion
CCDC8 serves as an independent biomarker for predicting prognosis and immunotherapy efficacy in bladder cancer.
Supporting Evidence
- High CCDC8 expression correlates with poor prognosis in bladder cancer.
- CCDC8 is linked to reduced response to immunotherapy.
- CCDC8 expression is associated with immune microenvironment modulation.
Takeaway
CCDC8 is a protein that can help doctors understand how serious bladder cancer is and how well treatments might work.
Methodology
The study used bioinformatics analysis and immunohistochemistry on data from public databases and a retrospective case series.
Potential Biases
Potential biases may arise from the retrospective nature of the study and selection criteria for cohorts.
Limitations
The study is limited by its retrospective design and reliance on existing datasets.
Participant Demographics
The study included 408 bladder cancer patients from TCGA and 100 patients for immunohistochemistry, with varying ages and stages.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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