Effects of Medicago sativa on Stroke Recovery in Mice
Author Information
Author(s): Bora Kundan Singh, Sharma Anupam
Primary Institution: L.R. Institute of Pharmacy, Solan, India
Hypothesis
Does Medicago sativa have neuroprotective effects against ischemia and reperfusion injury in mice?
Conclusion
Medicago sativa significantly reduces cerebral infarct size and enhances antioxidant defense in mice subjected to ischemia and reperfusion.
Supporting Evidence
- Pre-treatment with Medicago sativa reduced cerebral infarct size by 37.9% and 54.8% at doses of 100 and 200 mg/kg, respectively.
- Medicago sativa significantly restored levels of antioxidants like GSH, SOD, and T-SH in the brain.
- Behavioral tests showed that Medicago sativa improved short-term memory and motor coordination in mice after ischemia.
Takeaway
This study shows that a plant called Medicago sativa can help protect the brain from damage caused by a stroke in mice.
Methodology
The study used Swiss albino mice and assessed the effects of Medicago sativa on ischemia and reperfusion injury through various biochemical and behavioral tests.
Limitations
The study was conducted only in mice, and results may not directly translate to humans.
Participant Demographics
Swiss albino mice of either sex, weighing 20–30 g.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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