Automated Liquid-Liquid Extraction System
Author Information
Author(s): Eugene Maslana, Robert Schmitt, Jeffrey Pan
Primary Institution: Abbott Laboratories
Hypothesis
The automated system can efficiently perform liquid-liquid extraction on large sets of organic compounds used for drug discovery.
Conclusion
The automated liquid-liquid extraction station effectively extracts waste products with good yield and no contamination.
Supporting Evidence
- The system has processed over 6000 compounds in 18 months of operation.
- Compound purity of 99% is achievable with no detectable cross-contamination.
- Recovery rates for compounds ranged from 41% to 86.8%.
Takeaway
This machine helps scientists quickly separate liquids in test tubes without making a mess, saving them a lot of time.
Methodology
The system uses a cylindrical robot to shuttle vials, detects phase interfaces using refractive index, and performs extractions with various solvents.
Limitations
The high-yield mode can lower final yield in some cases, and certain chemistries may still pose challenges.
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