New Thinking on the Etiology and Pathogenesis of Late-Onset Alzheimer's Disease
2011
New Thinking on Late-Onset Alzheimer's Disease
Editorial
Author Information
Author(s): Alan P. Hudson, Brian J. Balin, Keith Crutcher, Stephen Robinson
Hypothesis
The etiology of late-onset Alzheimer's disease is influenced by a complex interplay of genetic and environmental factors.
Conclusion
The study suggests that late-onset Alzheimer's disease cannot be solely explained by the accumulation of amyloid plaques and neurofibrillary tangles.
Supporting Evidence
- The amyloid cascade hypothesis has been a dominant theory but may not fully explain late-onset Alzheimer's disease.
- Research indicates a need for identifying early markers of Alzheimer's disease.
- New studies suggest that certain genetic factors may help identify individuals at risk for Alzheimer's.
Takeaway
Scientists are trying to understand Alzheimer's disease better by looking at both genes and the environment, not just the brain plaques.
Digital Object Identifier (DOI)
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