Diphtheria Antitoxin Levels in the Netherlands: a Population-Based Study
Author Information
Author(s): H.E. de Melker, G.A.M. Berbers, N.J.D. Nagelkerke, M.A.E. Conyn-van Spaendonck
Primary Institution: National Institute of Public Health and the Environment
Hypothesis
What is the level of diphtheria immunity in the Dutch population and among those refusing vaccination?
Conclusion
The study found that while the Dutch immunization program provides long-term protection against diphtheria, a significant number of older adults and members of certain religious communities lack adequate immunity.
Supporting Evidence
- 58% of the Dutch population had full protection against diphtheria.
- 30% had basic protection, while 12% had no protection.
- Long-term protection was observed in those vaccinated after the program's introduction.
- Over 60% of orthodox reformed persons had no protective antibodies.
Takeaway
This study looked at how many people in the Netherlands are protected against diphtheria. It found that many older people and some groups who don't get vaccinated are not protected.
Methodology
Blood samples were collected from a population-based serum bank and tested for diphtheria antitoxin antibodies using a toxin-binding inhibition assay.
Potential Biases
Potential bias due to lower participation rates in certain demographics, particularly among those refusing vaccination.
Limitations
The study's estimates may not fully account for nonparticipation bias, although participation rates were considered representative.
Participant Demographics
Participants included a nationwide sample and members of religious communities with low vaccine coverage.
Statistical Information
Confidence Interval
95% CI reported for various immunity levels.
Want to read the original?
Access the complete publication on the publisher's website