Antibodies against Lagos Bat Virus in West African Bats
Author Information
Author(s): Hayman David T.S., Fooks Anthony R., Horton Daniel, Suu-Ire Richard, Breed Andrew C., Cunningham Andrew A., Wood James L.N.
Primary Institution: University of Cambridge
Hypothesis
To investigate the presence of Lagos bat virus (LBV)–specific antibodies in megachiroptera from West Africa.
Conclusion
The study confirmed the presence of LBV antibodies in healthy E. helvum bats in Ghana, indicating high seroprevalence rates.
Supporting Evidence
- Neutralizing antibodies were detected in Eidolon helvum (37%), Epomophorus gambianus (3%), and Epomops buettikoferi (33%, 2/6) from Ghana.
- Nine seropositive bats were apparently healthy pregnant females.
- LBV likely co-evolved with its natural megachiropteran host until a genetic stasis had been reached.
Takeaway
Researchers found that many bats in West Africa have antibodies against a virus called Lagos bat virus, which means they have been exposed to it but may not be sick.
Methodology
Bats were captured and tested for LBV antibodies using fluorescent antibody virus neutralization tests.
Limitations
The study did not investigate infections in humans and had difficulty determining the age of adult bats.
Participant Demographics
Bats were captured from various habitats in Ghana, including urban and forested areas.
Statistical Information
Confidence Interval
95% CI 24%–49%
Statistical Significance
p>0.9
Digital Object Identifier (DOI)
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