CYP2C19 Activity in Gujrati and Marwadi Subjects
Author Information
Author(s): Panchabhai Tanmay S, Noronha Shaun F, Davis Sanish, Shinde Vishal M, Kshirsagar Nilima A, Gogtay Nithya J
Primary Institution: Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai, India
Hypothesis
The study evaluates the activity of CYP2C19 in normal, healthy Gujrati and Marwadi subjects.
Conclusion
A genotyping evaluation would better help in identifying population specific genotypes and thus help individualize drug therapy.
Supporting Evidence
- 10.36% of the population were poor metabolizers, while 89.63% were extensive metabolizers.
- The mean metabolic ratio of the population was 6.52.
- Omeprazole is a valuable probe drug for establishing the genotype-phenotype correlation for CYP2C19.
Takeaway
This study looked at how different people in Mumbai process a medicine called omeprazole, which is important for treating stomach issues.
Methodology
Subjects received 20 mg of omeprazole, followed by blood collection to estimate the metabolic ratio of omeprazole to 5-hydroxyomeprazole, analyzed by HPLC.
Limitations
The number of poor metabolizers was too small for meaningful statistical analysis.
Participant Demographics
The study included 164 normal healthy subjects, with 110 males and 54 females, mean age 24.79 years.
Statistical Information
Confidence Interval
95% CI; 26.55, 23.03
Digital Object Identifier (DOI)
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