Sensing and Integration of Erk and PI3K Signals by Myc
2008
How Myc Integrates Signals from Erk and PI3K
publication
Evidence: moderate
Author Information
Author(s): Lee Tae, Yao Guang, Nevins Joseph, You Lingchong
Primary Institution: Duke University
Hypothesis
How do Erk and PI3K signals regulate Myc dynamics at the post-translational level?
Conclusion
Myc integrates Erk and PI3K signals to control various cellular responses through differential stability of its protein isoforms.
Supporting Evidence
- Myc is regulated by two Ras effector pathways: Erk and PI3K.
- The model predicts that Myc accumulation is sensitive to the duration and residual levels of Erk and PI3K signals.
- Sequential phosphorylation of Myc allows it to integrate signals from Erk and PI3K effectively.
Takeaway
Myc is like a switch that helps cells decide whether to grow or die, and it listens to two signals to make that decision.
Methodology
A mathematical model was developed to analyze the post-translational regulation of Myc via sequential phosphorylation by Erk and PI3K.
Limitations
The model assumes saturation of input signals and does not account for all potential regulatory mechanisms.
Digital Object Identifier (DOI)
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