The hypothalamic–pituitary–thyroid axis, depression and risk of suicide: commentary, Luo et al
2024
Thyroid Function, Depression, and Suicide Risk
Sample size: 1718
Commentary
Evidence: moderate
Author Information
Author(s): Charles B. Nemeroff
Primary Institution: The University of Texas at Austin Dell Medical School
Conclusion
The study highlights a significant relationship between autoimmune thyroiditis and increased suicide attempts in patients with major depression.
Supporting Evidence
- The study found that 25.8% of depressed patients had detectable anti-thyroid antibodies.
- Patients with thyroid antibodies had a lifetime suicide attempt rate of 34%, compared to 14% in those without.
- High antibody titres were associated with even higher suicide attempt rates of 44% (TgAb) and 54% (TPOAb).
Takeaway
This study found that people with depression and thyroid problems are more likely to have tried to hurt themselves. Checking thyroid health could help doctors treat depression better.
Limitations
The commentary is based on existing literature and does not present new experimental data.
Participant Demographics
First-episode, drug-free patients with major depression.
Digital Object Identifier (DOI)
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