The clinical significance of MMP-1 expression in oesophageal carcinoma
2001
The Role of MMP-1 in Oesophageal Cancer
Sample size: 51
publication
Evidence: moderate
Author Information
Author(s): Yamashita K, Mori M, Kataoka A, Inoue H, Sugimachi K
Primary Institution: Medical Institute of Bioregulation, Kyushu University
Hypothesis
MMP-1 expression is significant in oesophageal carcinoma and may serve as a prognostic factor.
Conclusion
MMP-1 is involved in the invasive process of oesophageal carcinoma and may be a novel prognostic factor.
Supporting Evidence
- MMP-1 mRNA was expressed in 94.1% of carcinoma tissue specimens.
- The mean T/N ratio of MMP-1 was 42.5.
- Higher T/N ratios were associated with a greater incidence of muscularis propria involvement.
- MMP-1 mRNA was significantly associated with gelatinolytic bands indicating active and latent forms.
- MMP-1 mRNA levels were inversely correlated with patient prognosis.
Takeaway
MMP-1 is a protein that helps cancer cells invade tissues, and its presence can indicate how serious the cancer is.
Methodology
Reverse transcription-polymerase chain reaction was used to analyze MMP-1 mRNA expression in tissue specimens.
Participant Demographics
Patients with oesophageal carcinoma.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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